Patrick Asher ’23, Riley Hughes ’23, and Giancarlo Irizarry ’23
Progress towards the synthesis of chiral heterobiaryl atropisomers via [2+2+2] cyclotrimerization
Patrick Asher ’23 Chemistry major
Riley Hughes ’23, Biochemistry major
Giancarlo Irizarry ’23, Chemistry major
Faculty Mentor: Dr. Seann Mulcahy, Chemistry and Biochemistry
A suite of novel, bio-inspired atropisomeric β-carbolines were modeled and their theoretical energetic barriers to rotation were calculated. A select group of these molecules were then synthesized both as a racemate and asymmetrically, in order to further investigate their physicochemical and stereochemical properties. Here we present a novel synthesis of chiral heterobiaryl atropisomers via [2+2+2] cyclotrimerization.
Poster Presentation: Wednesday, April 26, 2 – 4 p.m.
