Investigating Pathways Regulating Size-Dependent Accumulation of Mitotic Activator Cdc25
Investigating Pathways Regulating Size-Dependent Accumulation of Mitotic Activator Cdc25
Paige Duggan ’26, Biology major, Neuroscience and Math minor
Logan Anglemyer ’26, Neuroscience major, Spanish minor
Kayleigh Goebelbecker ’24, Biology major
Faculty Mentor: Dr. Kristi Miller, Biology
Poster Presentation: Wednesday, April 24, 11 a.m. – 12:30 p.m.
Cells maintain a characteristic size to function. Abnormal cell size is characteristic of cancer cells, but it’s unclear how healthy or diseased cells control their size. We use fission yeast to study cell size control because of their easy-to-measure rod shape. Fission yeast control their size in part though size-dependent nuclear accumulation of mitotic activator Cdc25. In this study, we investigate the pathways that influence the nuclear accumulation of Cdc25 in response to changes in cell size using quantitative live-cell fluorescence microscopy. Our work has the potential to reveal conserved regulatory networks involved in cell size control.
